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On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
Crosschecked: 2023-02-09
Cited: 0
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Liensinine attenuates inflammation and oxidative stress in spleen tissue in an LPS-induced mouse sepsis model
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Hanyu WANG, Yuanhao YANG, Xiao ZHANG, Yan WANG, Hui FAN, Jinfeng SHI, Xuelian TAN, Baoshi XU, Jingchao QIANG, Enzhuang PAN, Mingyi CHU, Zibo DONG, Jingquan DONG. Liensinine attenuates inflammation and oxidative stress in spleen tissue in an LPS-induced mouse sepsis model[J]. Journal of Zhejiang University Science B, 2023, 24(2): 185-190.
@article{title="Liensinine attenuates inflammation and oxidative stress in spleen tissue in an LPS-induced mouse sepsis model",
author="Hanyu WANG, Yuanhao YANG, Xiao ZHANG, Yan WANG, Hui FAN, Jinfeng SHI, Xuelian TAN, Baoshi XU, Jingchao QIANG, Enzhuang PAN, Mingyi CHU, Zibo DONG, Jingquan DONG",
journal="Journal of Zhejiang University Science B",
volume="24",
number="2",
pages="185-190",
year="2023",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2200340"
}
%0 Journal Article
%T Liensinine attenuates inflammation and oxidative stress in spleen tissue in an LPS-induced mouse sepsis model
%A Hanyu WANG
%A Yuanhao YANG
%A Xiao ZHANG
%A Yan WANG
%A Hui FAN
%A Jinfeng SHI
%A Xuelian TAN
%A Baoshi XU
%A Jingchao QIANG
%A Enzhuang PAN
%A Mingyi CHU
%A Zibo DONG
%A Jingquan DONG
%J Journal of Zhejiang University SCIENCE B
%V 24
%N 2
%P 185-190
%@ 1673-1581
%D 2023
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2200340
TY - JOUR
T1 - Liensinine attenuates inflammation and oxidative stress in spleen tissue in an LPS-induced mouse sepsis model
A1 - Hanyu WANG
A1 - Yuanhao YANG
A1 - Xiao ZHANG
A1 - Yan WANG
A1 - Hui FAN
A1 - Jinfeng SHI
A1 - Xuelian TAN
A1 - Baoshi XU
A1 - Jingchao QIANG
A1 - Enzhuang PAN
A1 - Mingyi CHU
A1 - Zibo DONG
A1 - Jingquan DONG
J0 - Journal of Zhejiang University Science B
VL - 24
IS - 2
SP - 185
EP - 190
%@ 1673-1581
Y1 - 2023
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2200340
Abstract: sepsis is a complex syndrome caused by multiple pathogens and involves multiple organ failure, particularly spleen dysfunction. In 2017, the worldwide incidence was 48.9 million sepsis cases and 11 million sepsis-related deaths were reported (Rudd et al., 2020). Inflammation, oxidative stress, and apoptosis are the most common pathologies seen in sepsis. liensinine (LIE) is a bisbenzylisoquinoline-type alkaloid extracted from the seed embryo of Nelumbo nucifera. Lotus seed hearts have high content of LIE which mainly has antihypertensive and antiarrhythmic pharmacological effects. It can exert anti-carcinogenic activity by regulating cell, inflammation, and apoptosis signaling pathways (Manogaran et al., 2019). However, its protective effect from sepsis-induced spleen damage is unknown. In this research, we established a mouse sepsis model induced by lipopolysaccharide (LPS) and investigated the protective effects of LIE on sepsis spleen injury in terms of inflammatory response, oxidative stress, and apoptosis.
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