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Abstract: ceria nanoparticles (CeO₂ NPs) have become popular materials in biomedical and industrial fields due to their potential applications in anti-oxidation, cancer therapy, photocatalytic degradation of pollutants, sensors, etc. Many methods, including gas phase, solid phase, liquid phase, and the newly proposed green synthesis method, have been reported for the synthesis of CeO₂ NPs. Due to the wide application of CeO₂ NPs, concerns about their adverse impacts on human health have been raised. This review covers recent studies on the biomedical applications of CeO₂ NPs, including their use in the treatment of various diseases (e.‍g., Alzheimer’s disease, ischemic stroke, retinal damage, chronic inflammation, and cancer). CeO₂ NP toxicity is discussed in terms of the different systems of the human body (e.‍g., cytotoxicity, genotoxicity, respiratory toxicity, neurotoxicity, and hepatotoxicity). This comprehensive review covers both fundamental discoveries and exploratory progress in CeO₂ NP research that may lead to practical developments in the future.

二氧化铈纳米颗粒：生物医学应用和毒性

付晓暄¹，李鹏²，陈茜¹，马圆圆¹，王榕¹，姬文轩¹，谷家阔¹，生博文¹，王一州³，张竹红^1
1烟台大学药学院，分子药理学与药物评价教育部重点实验室，山东高校先进给药系统与生物技术药物协同创新中心，中国烟台市，264005
²青岛大学烟台毓璜顶医院肾内科，中国烟台市，264005
³浙江大学农业与生物技术学院作物科学研究所，中国杭州市，310058
摘要：二氧化铈纳米颗粒（CeO₂ NPs）因其在抗氧化、癌症治疗、光催化降解污染物和传感器等方面的潜在应用而成为生物医学和工业领域的热门材料。目前已经报道了气相、固相、液相以及新提出的绿色合成等多种合成CeO₂ NPs的方法。随着CeO₂ NPs的广泛应用，人们对其可能带来的健康隐患感到担忧。本文综述了近年来CeO₂ NPs在生物医学领域的应用研究，包括其对各种疾病（如阿尔茨海默病、缺血性中风、视网膜损伤、慢性炎症和癌症）的治疗，并讨论了CeO₂ NPs对人体的不同系统的毒性，如细胞毒性、遗传毒性、呼吸毒性、神经毒性和肝毒性。总之，该综述全面涵盖了CeO₂ NPs研究的重大发现及其探索性进展，对未来的实践发展具有重要的参考价值。

关键词：二氧化铈纳米颗粒；合成方法；生物医学应用程序；氧化应激；毒性

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