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Journal of Zhejiang University SCIENCE A 2002 Vol.3 No.3 P.378-380

http://doi.org/10.1631/jzus.2002.0378


Evaluation of cilazapril in vasovagal syncope treatment


Author(s):  HAN Yang, JIANG Wei-li, JIN Mei-zhen, GE Wei, CHEN Tian-zhi

Affiliation(s):  1st Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China

Corresponding email(s): 

Key Words:  Vasovagal syncope (VVS), Cilazapril, Blood pressure & heart rate, Tilt table test


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HAN Yang, JIANG Wei-li, JIN Mei-zhen, GE Wei, CHEN Tian-zhi. Evaluation of cilazapril in vasovagal syncope treatment[J]. Journal of Zhejiang University Science A, 2002, 3(3): 378-380.

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author="HAN Yang, JIANG Wei-li, JIN Mei-zhen, GE Wei, CHEN Tian-zhi",
journal="Journal of Zhejiang University Science A",
volume="3",
number="3",
pages="378-380",
year="2002",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.2002.0378"
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%A HAN Yang
%A JIANG Wei-li
%A JIN Mei-zhen
%A GE Wei
%A CHEN Tian-zhi
%J Journal of Zhejiang University SCIENCE A
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%D 2002
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2002.0378

TY - JOUR
T1 - Evaluation of cilazapril in vasovagal syncope treatment
A1 - HAN Yang
A1 - JIANG Wei-li
A1 - JIN Mei-zhen
A1 - GE Wei
A1 - CHEN Tian-zhi
J0 - Journal of Zhejiang University Science A
VL - 3
IS - 3
SP - 378
EP - 380
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Y1 - 2002
PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.2002.0378


Abstract: 
Objective: to evaluate cilazapril in vasovagal syncope treatment. Method: eighty-six cases of VVS patients found positive in TTT tilt were medicated with 2.5 mg cilazapril daily for three months and followed up by TTT. Results: seven cases quit due to cough or unexplained reason; 79 VVS patients had no more fainting spells; 75.95% of TTT results of patients changed to negative after 3 months therapy. The before and after cilazapril treatment average blood pressures (taken in lying position) were 121/73 mm Hg (1 mm Hg=0.133kPa) and 120/76 mm Hg respectively (P>0.05); and mean heart rates were 68.63±12.37/min and 70.13±13.15/min respectively with no significant changes (P>0.05). Conclusion: cilazapril was effective in treatment of VVS; did not affect normal blood pressure and heart rate; was safe; and had little side effect.

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Reference

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[2] Guan Wu,Liu Zuhua,Chen Dimin et al., 1999. Medication comparative research in treatment of vasovagal syncope. Chinese Journal of Practical Internal Medicine, 19(11):678-679(in Chinese, with English abstract).

[3] Han Yang, Jiang Weili, Ge Wei et al., 2001. Serious responsiveness during tilt-table test in the elderly and its prophylactic management. Chin J Geriatrics, 20(1):19-21(in Chinese, with English abstract).

[4] Kochiadakis,G.E., Rombola,A.T., Kanoupakis,E.M. et al., 1997. Assessment of autonomic function at rest and during tilt testing in patients with vasovagal syncope. Am Heart J, 134(3):459-466.

[5] Lippman,N., Stein, K.M., Lerman, B.B., 1994. Differiential therapeutic responses of patients with isoproterenol-dependent and isoproterenol-independent vasodepressor syncope. Am Heart J, 128: 1110-1116.

[6] Ren Ziwen,Wu Ning,Chen Mengyang et al., 1998.Suggestion of tilt table test for diagnosis of vasovagal syncope. Chin J Cardiol, 26(5):325-327 (in Chinese).

[7] Roul, G.,Riehl, Aleil V.,Germain, P. et al.,1997. Neurohormonal profile before and after beta-blockade in patients with neurocardiogenic syncope. Pacing Clin Electrophysiol, 22(7):1020-1030.

[8] Zeng Chunyu, Liu Guangyao, Wang Xuekai et al., 1998. Discussion of therapeutic observation and machinism in elderly VVS with enapril treatment. Chin J Geriatrics, 17(3):184-185(in Chinese, with English abstract).

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