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On-line Access: 2010-10-05

Received: 2009-12-11

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Journal of Zhejiang University SCIENCE B 2010 Vol.11 No.10 P.784-791


Epigenetic regulation of adipocyte differentiation and adipogenesis

Author(s):  Hong-xing Li, Lei Xiao, Cheng Wang, Jia-li Gao, Yong-gong Zhai

Affiliation(s):  Key Laboratory for Cell Proliferation and Regulation Biology of Ministry of Education, College of Life Sciences, Beijing Normal University, Beijing 100875, China; more

Corresponding email(s):   ygzhai@bnu.edu.cn

Key Words:  Epigenetic regulation, Histone modification, DNA methylation, Differentiation, Adipogenesis

Hong-xing Li, Lei Xiao, Cheng Wang, Jia-li Gao, Yong-gong Zhai. Epigenetic regulation of adipocyte differentiation and adipogenesis[J]. Journal of Zhejiang University Science B, 2010, 11(10): 784-791.

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author="Hong-xing Li, Lei Xiao, Cheng Wang, Jia-li Gao, Yong-gong Zhai",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Epigenetic regulation of adipocyte differentiation and adipogenesis
%A Hong-xing Li
%A Lei Xiao
%A Cheng Wang
%A Jia-li Gao
%A Yong-gong Zhai
%J Journal of Zhejiang University SCIENCE B
%V 11
%N 10
%P 784-791
%@ 1673-1581
%D 2010
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B0900401

T1 - Epigenetic regulation of adipocyte differentiation and adipogenesis
A1 - Hong-xing Li
A1 - Lei Xiao
A1 - Cheng Wang
A1 - Jia-li Gao
A1 - Yong-gong Zhai
J0 - Journal of Zhejiang University Science B
VL - 11
IS - 10
SP - 784
EP - 791
%@ 1673-1581
Y1 - 2010
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B0900401

It is generally agreed that adipocytes originate from mesenchymal stem cells in what can be divided into two processes: determination and differentiation. In the past decade, many factors associated with epigenetic signals have been proved to be pivotal for the appropriate timing of adipogenesis progression. A large number of coregulators at critical gene promoters set up specific patterns of DNA methylation, histone acetylation and methylation, and nucleosome rearrangement, that act as an epigenetic code to modulate the correct progress of adipocyte differentiation and adipogenesis during adipogenesis. In this review, we focus on the functions and roles of epigenetic processes in preadipocyte differentiation and adipogenesis.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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