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On-line Access: 2011-11-04

Received: 2010-11-05

Revision Accepted: 2011-03-08

Crosschecked: 2011-09-30

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Journal of Zhejiang University SCIENCE B 2011 Vol.12 No.11 P.900-908


Involvement of basolateral amygdala GABAA receptors in the effect of dexamethasone on memory in rats

Author(s):  Lotfollah Khajehpour, Acieh Alizadeh-Makvandi, Mahnaz Kesmati, Hooman Eshagh-Harooni

Affiliation(s):  Department of Biology, College of Science, Shahid Chamran University of Ahvaz, Ahvaz, Iran

Corresponding email(s):   khajehpour@scu.ac.ir

Key Words:  Basolateral amygdala, Dexamethasone, Muscimol, Bicuculline, Passive avoidance task

Lotfollah Khajehpour, Acieh Alizadeh-Makvandi, Mahnaz Kesmati, Hooman Eshagh-Harooni. Involvement of basolateral amygdala GABAA receptors in the effect of dexamethasone on memory in rats[J]. Journal of Zhejiang University Science B, 2011, 12(11): 900-908.

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author="Lotfollah Khajehpour, Acieh Alizadeh-Makvandi, Mahnaz Kesmati, Hooman Eshagh-Harooni",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Involvement of basolateral amygdala GABAA receptors in the effect of dexamethasone on memory in rats
%A Lotfollah Khajehpour
%A Acieh Alizadeh-Makvandi
%A Mahnaz Kesmati
%A Hooman Eshagh-Harooni
%J Journal of Zhejiang University SCIENCE B
%V 12
%N 11
%P 900-908
%@ 1673-1581
%D 2011
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1000340

T1 - Involvement of basolateral amygdala GABAA receptors in the effect of dexamethasone on memory in rats
A1 - Lotfollah Khajehpour
A1 - Acieh Alizadeh-Makvandi
A1 - Mahnaz Kesmati
A1 - Hooman Eshagh-Harooni
J0 - Journal of Zhejiang University Science B
VL - 12
IS - 11
SP - 900
EP - 908
%@ 1673-1581
Y1 - 2011
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1000340

In this study we investigated whether GABAA receptors of the basolateral amygdala (BLA) interact with the effect of dexamethasone on the retrieval stage of memory. Adult male Wistar rats were bilaterally cannulated in the BLA by stereotaxic surgery. The animals were trained in step-through apparatus by induction of electric shock (1.5 mA, 3 s) and were tested for memory retrieval after 1 d. The time of latency for entering the dark compartment of the instrument and the time spent by rats in this chamber were recorded for evaluation of the animals’ retrieval in passive avoidance memory. Administration of dexamethasone (0.3 and 0.9 mg/kg, subcutaneously (s.c.)), immediately after training, enhanced memory retrieval. This effect was reduced by intra-BLA microinjection of muscimol (0.125, 0.250 and 0.500 µg/rat), when administered before 0.9 mg/kg of dexamethasone. Microinjection of bicuculline (0.75 µg/rat, intra-BLA) with an ineffective dose of dexamethasone (0.1 mg/kg, s.c.) increased memory retrieval. However, the same doses of muscimol and bicuculline without dexamethasone did not affect memory processes. Our data support reports that dexamethasone enhances memory retrieval. It seems that GABAA receptors of the BLA mediate the effect of dexamethasone on memory retrieval in rats.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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