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CLC number: R446

On-line Access: 2015-01-05

Received: 2014-06-30

Revision Accepted: 2014-11-06

Crosschecked: 2014-12-20

Cited: 13

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Citations:  Bibtex RefMan EndNote GB/T7714




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Journal of Zhejiang University SCIENCE B 2015 Vol.16 No.1 P.78-86


Elevated homocysteine levels and risk of cardiovascular and all-cause mortality: a meta-analysis of prospective studies

Author(s):  Hui-yong Peng, Chang-feng Man, Juan Xu, Yu Fan

Affiliation(s):  Cancer Institute, the Affiliated People’s Hospital, Jiangsu University, Zhenjiang 212002, China

Corresponding email(s):   jszjfanyu@163.com

Key Words:  Homocysteine, Coronary heart disease, Cardiovascular mortality, All-cause mortality, Meta-analysis

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Hui-yong Peng, Chang-feng Man, Juan Xu, Yu Fan. Elevated homocysteine levels and risk of cardiovascular and all-cause mortality: a meta-analysis of prospective studies[J]. Journal of Zhejiang University Science B, 2015, 16(1): 78-86.

@article{title="Elevated homocysteine levels and risk of cardiovascular and all-cause mortality: a meta-analysis of prospective studies",
author="Hui-yong Peng, Chang-feng Man, Juan Xu, Yu Fan",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Elevated homocysteine levels and risk of cardiovascular and all-cause mortality: a meta-analysis of prospective studies
%A Hui-yong Peng
%A Chang-feng Man
%A Juan Xu
%A Yu Fan
%J Journal of Zhejiang University SCIENCE B
%V 16
%N 1
%P 78-86
%@ 1673-1581
%D 2015
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1400183

T1 - Elevated homocysteine levels and risk of cardiovascular and all-cause mortality: a meta-analysis of prospective studies
A1 - Hui-yong Peng
A1 - Chang-feng Man
A1 - Juan Xu
A1 - Yu Fan
J0 - Journal of Zhejiang University Science B
VL - 16
IS - 1
SP - 78
EP - 86
%@ 1673-1581
Y1 - 2015
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1400183

Objective: To investigate whether elevated homocysteine levels were a predictor of subsequent coronary heart disease (CHD) mortality, cardiovascular mortality or all-cause mortality in the general population by a meta-analysis. Methods: In a systematic search conducted in the databases of PubMed and Embase prior to October 2013, we identified relevant prospective observational studies evaluating the association between baseline homocysteine levels and CHD mortality, cardiovascular or all-cause mortality in the general population. Pooled adjust risk ratio (RR) and corresponding 95% confidence interval (CI) were calculated separately for categorical risk estimates and continuous risk estimates. Results: Twelve studies with 23623 subjects were included in the meta-analysis. Comparing the highest to lowest homocysteine level categories, CHD mortality increased by 66% (RR 1.66; 95% CI 1.12–2.47; P=0.012), cardiovascular mortality increased by 68% (RR 1.68; 95% CI 1.04–2.70; P=0.033), and all-cause mortality increased by 93% (RR 1.93; 95% CI 1.54–2.43; P<0.001). Moreover, for each 5 μmol/L homocysteine increment, the pooled RR was 1.52 (95% CI 1.26–1.84; P<0.001) for CHD mortality, 1.32 (95% CI 1.08–1.61; P=0.006) for cardiovascular mortality, and 1.27 (95% CI 1.03–1.55; P=0.023) for all-cause mortality. Conclusions: Elevated homocysteine levels are an independent predictor for subsequent cardiovascular mortality or all-cause mortality, and the risks were more pronounced among elderly persons.




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