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CLC number: R446

On-line Access: 2024-08-27

Received: 2023-10-17

Revision Accepted: 2024-05-08

Crosschecked: 2014-12-20

Cited: 13

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Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Yu FAN

http://orcid.org/0000-0003-4095-8427

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Journal of Zhejiang University SCIENCE B 2015 Vol.16 No.1 P.78-86

http://doi.org/10.1631/jzus.B1400183


Elevated homocysteine levels and risk of cardiovascular and all-cause mortality: a meta-analysis of prospective studies


Author(s):  Hui-yong Peng, Chang-feng Man, Juan Xu, Yu Fan

Affiliation(s):  Cancer Institute, the Affiliated Peoples Hospital, Jiangsu University, Zhenjiang 212002, China

Corresponding email(s):   jszjfanyu@163.com

Key Words:  Homocysteine, Coronary heart disease, Cardiovascular mortality, All-cause mortality, Meta-analysis


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Hui-yong Peng, Chang-feng Man, Juan Xu, Yu Fan. Elevated homocysteine levels and risk of cardiovascular and all-cause mortality: a meta-analysis of prospective studies[J]. Journal of Zhejiang University Science B, 2015, 16(1): 78-86.

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volume="16",
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publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1400183"
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%A Juan Xu
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T1 - Elevated homocysteine levels and risk of cardiovascular and all-cause mortality: a meta-analysis of prospective studies
A1 - Hui-yong Peng
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DOI - 10.1631/jzus.B1400183


Abstract: 
Objective: To investigate whether elevated homocysteine levels were a predictor of subsequent coronary heart disease (CHD) mortality, cardiovascular mortality or all-cause mortality in the general population by a meta-analysis. Methods: In a systematic search conducted in the databases of PubMed and Embase prior to October 2013, we identified relevant prospective observational studies evaluating the association between baseline homocysteine levels and CHD mortality, cardiovascular or all-cause mortality in the general population. Pooled adjust risk ratio (RR) and corresponding 95% confidence interval (CI) were calculated separately for categorical risk estimates and continuous risk estimates. Results: Twelve studies with 23623 subjects were included in the meta-analysis. Comparing the highest to lowest homocysteine level categories, CHD mortality increased by 66% (RR 1.66; 95% CI 1.12–2.47; P=0.012), cardiovascular mortality increased by 68% (RR 1.68; 95% CI 1.04–2.70; P=0.033), and all-cause mortality increased by 93% (RR 1.93; 95% CI 1.54–2.43; P<0.001). Moreover, for each 5 μmol/L homocysteine increment, the pooled RR was 1.52 (95% CI 1.26–1.84; P<0.001) for CHD mortality, 1.32 (95% CI 1.08–1.61; P=0.006) for cardiovascular mortality, and 1.27 (95% CI 1.03–1.55; P=0.023) for all-cause mortality. Conclusions: Elevated homocysteine levels are an independent predictor for subsequent cardiovascular mortality or all-cause mortality, and the risks were more pronounced among elderly persons.

血浆同型半胱氨酸水平升高与心血管疾病及各种死亡风险因子的meta分析

目的:探讨普通人群血浆同型半胱氨酸水平升高是否能独立预测死亡风险。
创新点:通过汇总12篇前瞻性研究,定量分析血浆同型半胱氨酸水平升高与心血管疾病及各种死亡风险因子的关系。
方法:通过检索PubMed和Embase数据库,收集普通人群中血浆同型半胱氨酸水平与死亡关系的前瞻性观察性研究,采用STATA统计软件进行meta分析。
结论:血浆同型半胱氨酸水平升高是心血管疾病及各种原因死亡风险增加的一个独立预测因素,在老年人群中尤为明显。

关键词:同型半胱氨酸;冠状动脉疾病;心血管死亡;全因性死亡;meta分析

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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