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Journal of Zhejiang University SCIENCE B 1998 Vol.-1 No.-1 P.

http://doi.org/10.1631/jzus.B2200243


Exosome-mediated regulatory mechanisms in skeletal muscle: A narrative review


Author(s):  Zhaolu WANG, Jinjin YANG, Xiaohui SUN, Xi SUN, Gongshe YANG, Xin’,e SHI

Affiliation(s):  College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China

Corresponding email(s):   xineshi@nwafu.edu.cn

Key Words:  Exosome, Skeletal muscle, Muscle atrophy, Insulin resistance


Zhaolu WANG, Jinjin YANG, Xiaohui SUN, Xi SUN, Gongshe YANG, Xin’e SHI. Exosome-mediated regulatory mechanisms in skeletal muscle: A narrative review[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .

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%A Zhaolu WANG
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Abstract: 
skeletal muscle plays a paramount role in physical activity, metabolism and energy balance, while its homeostasis is being challenged by multiple unfavorable factors such as injury, aging or obesity. exosomes, a subset of extracellular vesicles, are now recognized as essential mediators of intercellular communication, holding great clinical potential in the treatment of skeletal muscle diseases. Herein, we outline the recent research progress in exosomal isolation, characterization and mechanism of action, and emphatically discuss current advances in exosomes derived from multiple organs, tissues, and engineered exosomes regarding the regulation of physiological and pathological development of skeletal muscle. These remarkable advances expand our understanding of myogenesis and muscle diseases. Meanwhile, the engineered exosome, as an endogenous nanocarrier combined with advanced design methodologies of biomolecules, will help to open up innovative therapeutic perspectives for the treatment of muscle diseases.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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