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Luqiao WANG

https://orcid.org/0000-0003-0263-9492

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Journal of Zhejiang University SCIENCE B 2023 Vol.24 No.4 P.281-300

http://doi.org/10.1631/jzus.B2200459


Promising roles of non-exosomal and exosomal non-coding RNAs in the regulatory mechanism and as diagnostic biomarkers in myocardial infarction


Author(s):  Jingru LI, Haocheng MA, Xinyu WU, Guihu SUN, Ping YANG, Yunzhu PENG, Qixian WANG, Luqiao WANG

Affiliation(s):  Department of Cardiology, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, China

Corresponding email(s):   wlq8360@163.com

Key Words:  Exosome, Non-exosomal non-coding RNA (ncRNA), Exosomal ncRNA, Long non-coding RNA (lncRNA), MicroRNA (miRNA), Circular RNA (circRNA), Myocardial Infarction (MI)


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Jingru LI, Haocheng MA, Xinyu WU, Guihu SUN, Ping YANG, Yunzhu PENG, Qixian WANG, Luqiao WANG. Promising roles of non-exosomal and exosomal non-coding RNAs in the regulatory mechanism and as diagnostic biomarkers in myocardial infarction[J]. Journal of Zhejiang University Science B, 2023, 24(4): 281-300.

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author="Jingru LI, Haocheng MA, Xinyu WU, Guihu SUN, Ping YANG, Yunzhu PENG, Qixian WANG, Luqiao WANG",
journal="Journal of Zhejiang University Science B",
volume="24",
number="4",
pages="281-300",
year="2023",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2200459"
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%T Promising roles of non-exosomal and exosomal non-coding RNAs in the regulatory mechanism and as diagnostic biomarkers in myocardial infarction
%A Jingru LI
%A Haocheng MA
%A Xinyu WU
%A Guihu SUN
%A Ping YANG
%A Yunzhu PENG
%A Qixian WANG
%A Luqiao WANG
%J Journal of Zhejiang University SCIENCE B
%V 24
%N 4
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%@ 1673-1581
%D 2023
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2200459

TY - JOUR
T1 - Promising roles of non-exosomal and exosomal non-coding RNAs in the regulatory mechanism and as diagnostic biomarkers in myocardial infarction
A1 - Jingru LI
A1 - Haocheng MA
A1 - Xinyu WU
A1 - Guihu SUN
A1 - Ping YANG
A1 - Yunzhu PENG
A1 - Qixian WANG
A1 - Luqiao WANG
J0 - Journal of Zhejiang University Science B
VL - 24
IS - 4
SP - 281
EP - 300
%@ 1673-1581
Y1 - 2023
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2200459


Abstract: 
Non-exosomal non-coding RNAs (non-exo-ncRNAs) and exosomal ncRNAs (exo-ncRNAs) have been associated with the pathological development of myocardial Infarction (MI). Accordingly, this analytical review provides an overview of current MI studies on the role of plasma non-exo/exo-ncRNAs. We summarize the features and crucial roles of ncRNAs and reveal their novel biological correlations via bioinformatics analysis. The following contributions are made: (1) we comprehensively describe the expression profile, competing endogenous RNA (ceRNA) network, and “pre-necrotic” biomarkers of non-exo/exo-ncRNAs for MI; (2) functional enrichment analysis indicates that the target genes of ncRNAs are enriched in the regulation of apoptotic signaling pathway and cellular response to chemical stress, etc.; (3) we propose an updated and comprehensive view on the mechanisms, pathophysiology, and biomarker roles of non-exo/exo-ncRNAs in MI, thereby providing a theoretical basis for the clinical management of MI.

非外泌体/外泌体非编码RNAs在参与心肌梗死调节及作为诊断性生物标志物方面的作用

李静茹,马浩诚,吴新宇,孙贵虎,杨萍,彭云珠,王启贤,王路乔
昆明医科大学第一附属医院心内科,中国昆明市,650032
摘要:非外泌体/外泌体非编码RNAs与心肌梗死(MI)的病理发展相关。本文对目前血浆中非外泌体/外泌体非编码RNAs在MI中的作用进行了概述,总结了上述非编码RNAs的特点和关键作用,并通过生物信息学分析揭示其新的生物学关联性,内容包括:(1)全面描述了MI中非外泌体/外泌体非编码RNAs的表达、内源竞争RNA网络和"坏死前"的生物标志物;(2)分析证实非编码RNAs的靶基因在调控细胞凋亡信号通路和细胞对化学应激反应等过程中富集;(3)对非外泌体/外泌体非编码RNAs在MI中的调节机制、病理生理学功能和作为生物标志物方面的作用提出了新的视角,为其临床治疗提供理论依据。

关键词:外泌体;非外泌体非编码RNA(ncRNA);外泌体ncRNA;长链非编码RNA(lncRNA);微小RNA(miRNA);环状RNA(circRNA);心肌梗死

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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