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Luqiao WANG


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Journal of Zhejiang University SCIENCE B 2023 Vol.24 No.4 P.281-300


Promising roles of non-exosomal and exosomal non-coding RNAs in the regulatory mechanism and as diagnostic biomarkers in myocardial infarction

Author(s):  Jingru LI, Haocheng MA, Xinyu WU, Guihu SUN, Ping YANG, Yunzhu PENG, Qixian WANG, Luqiao WANG

Affiliation(s):  Department of Cardiology, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, China

Corresponding email(s):   wlq8360@163.com

Key Words:  Exosome, Non-exosomal non-coding RNA (ncRNA), Exosomal ncRNA, Long non-coding RNA (lncRNA), MicroRNA (miRNA), Circular RNA (circRNA), Myocardial Infarction (MI)

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Jingru LI, Haocheng MA, Xinyu WU, Guihu SUN, Ping YANG, Yunzhu PENG, Qixian WANG, Luqiao WANG. Promising roles of non-exosomal and exosomal non-coding RNAs in the regulatory mechanism and as diagnostic biomarkers in myocardial infarction[J]. Journal of Zhejiang University Science B, 2023, 24(4): 281-300.

@article{title="Promising roles of non-exosomal and exosomal non-coding RNAs in the regulatory mechanism and as diagnostic biomarkers in myocardial infarction",
author="Jingru LI, Haocheng MA, Xinyu WU, Guihu SUN, Ping YANG, Yunzhu PENG, Qixian WANG, Luqiao WANG",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Promising roles of non-exosomal and exosomal non-coding RNAs in the regulatory mechanism and as diagnostic biomarkers in myocardial infarction
%A Jingru LI
%A Haocheng MA
%A Xinyu WU
%A Guihu SUN
%A Ping YANG
%A Yunzhu PENG
%A Qixian WANG
%A Luqiao WANG
%J Journal of Zhejiang University SCIENCE B
%V 24
%N 4
%P 281-300
%@ 1673-1581
%D 2023
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2200459

T1 - Promising roles of non-exosomal and exosomal non-coding RNAs in the regulatory mechanism and as diagnostic biomarkers in myocardial infarction
A1 - Jingru LI
A1 - Haocheng MA
A1 - Xinyu WU
A1 - Guihu SUN
A1 - Ping YANG
A1 - Yunzhu PENG
A1 - Qixian WANG
A1 - Luqiao WANG
J0 - Journal of Zhejiang University Science B
VL - 24
IS - 4
SP - 281
EP - 300
%@ 1673-1581
Y1 - 2023
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2200459

Non-exosomal non-coding RNAs (non-exo-ncRNAs) and exosomal ncRNAs (exo-ncRNAs) have been associated with the pathological development of myocardial Infarction (MI). Accordingly, this analytical review provides an overview of current MI studies on the role of plasma non-exo/exo-ncRNAs. We summarize the features and crucial roles of ncRNAs and reveal their novel biological correlations via bioinformatics analysis. The following contributions are made: (1) we comprehensively describe the expression profile, competing endogenous RNA (ceRNA) network, and “pre-necrotic” biomarkers of non-exo/exo-ncRNAs for MI; (2) functional enrichment analysis indicates that the target genes of ncRNAs are enriched in the regulation of apoptotic signaling pathway and cellular response to chemical stress, etc.; (3) we propose an updated and comprehensive view on the mechanisms, pathophysiology, and biomarker roles of non-exo/exo-ncRNAs in MI, thereby providing a theoretical basis for the clinical management of MI.




Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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