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CLC number: R735.3

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Received: 2005-09-17

Revision Accepted: 2005-11-01

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Journal of Zhejiang University SCIENCE B 2005 Vol.6 No.12 P.1163-1169


Prognostic significance of bcl-2 and p53 expression in colorectal carcinoma

Author(s):  ZHAO Dan-ping, DING Xiao-wen, PENG Jia-ping, ZHENG Yi-xiong, ZHANG Su-zhan

Affiliation(s):  Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China

Corresponding email(s):   zhangscy@tom.com

Key Words:  Colorectal carcinoma, bcl-2, p53, Prognosis

ZHAO Dan-ping, DING Xiao-wen, PENG Jia-ping, ZHENG Yi-xiong, ZHANG Su-zhan. Prognostic significance of bcl-2 and p53 expression in colorectal carcinoma[J]. Journal of Zhejiang University Science B, 2005, 6(12): 1163-1169.

@article{title="Prognostic significance of bcl-2 and p53 expression in colorectal carcinoma",
author="ZHAO Dan-ping, DING Xiao-wen, PENG Jia-ping, ZHENG Yi-xiong, ZHANG Su-zhan",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Prognostic significance of bcl-2 and p53 expression in colorectal carcinoma
%A ZHAO Dan-ping
%A DING Xiao-wen
%A PENG Jia-ping
%A ZHENG Yi-xiong
%A ZHANG Su-zhan
%J Journal of Zhejiang University SCIENCE B
%V 6
%N 12
%P 1163-1169
%@ 1673-1581
%D 2005
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2005.B1163

T1 - Prognostic significance of bcl-2 and p53 expression in colorectal carcinoma
A1 - ZHAO Dan-ping
A1 - DING Xiao-wen
A1 - PENG Jia-ping
A1 - ZHENG Yi-xiong
A1 - ZHANG Su-zhan
J0 - Journal of Zhejiang University Science B
VL - 6
IS - 12
SP - 1163
EP - 1169
%@ 1673-1581
Y1 - 2005
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2005.B1163

Objective: This study was designed to detect the expression of bcl-2 and p53 proteins in colorectal carcinomas and to determine their association with the patient survival and stage of the diseases. Methods: Immunohistochemistry method was used to detect the expression of bcl-2 and p53 proteins in 93 cases of colorectal carcinoma. The stain results were obtained by analyzing the clinic-pathological characteristics of patients. Results: Fifty-seven percent (53/93) of the colorectal carcinomas were bcl-2 protein positive. The positive rate of bcl-2 protein in lymph node involvement cases was lower (15/37) than the cases without node involvement (38/58, P<0.01). The positive rate of p53 protein was 43% (40/93) in colon-rectum carcinomas. No significant correlation was observed between p53 protein expression and clinic-pathological manifestations (P>0.05) but the survival was significantly worse (P=0.0001) in the p53 protein positive cases. Neither bcl-2 nor p53 alone was correlated with stage of the disease. When combined bcl-2/p53 status was analyzed, a group with bcl-2(+) and p53(−) had the best prognosis. This group was significantly associated with earlier Dukes’ stages (P=0.1763). In multivariate Cox regression analysis, lymph node involvement and p53 protein expression were two independent factors correlated with survival time. Conclusion: The expression of bcl-2 and p53 represent biological characteristics of colorectal carcinomas. Assessment of both bcl-2 and p53 status may be valuable in predicting the prognosis of patients.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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