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Zhi Chen


Jingwen DENG


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Journal of Zhejiang University SCIENCE B 2022 Vol.23 No.4 P.265-285


Molecular pathogenesis of acetaminophen-induced liver injury and its treatment options

Author(s):  Xiaopeng CAI, Huiqiang CAI, Jing WANG, Qin YANG, Jun GUAN, Jingwen DENG, Zhi CHEN

Affiliation(s):  State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China; more

Corresponding email(s):   zjuchenzhi@zju.edu.cn, jwdeng@zju.edu.cn

Key Words:  Acetaminophen, Acetaminophen-induced liver injury, Hepatocyte necrosis, Sterile inflammation, Hepatocyte regeneration

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Xiaopeng CAI, Huiqiang CAI, Jing WANG, Qin YANG, Jun GUAN, Jingwen DENG, Zhi CHEN. Molecular pathogenesis of acetaminophen-induced liver injury and its treatment options[J]. Journal of Zhejiang University Science B, 2022, 23(4): 265-285.

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author="Xiaopeng CAI, Huiqiang CAI, Jing WANG, Qin YANG, Jun GUAN, Jingwen DENG, Zhi CHEN",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

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%T Molecular pathogenesis of acetaminophen-induced liver injury and its treatment options
%A Xiaopeng CAI
%A Huiqiang CAI
%A Jing WANG
%A Jingwen DENG
%J Journal of Zhejiang University SCIENCE B
%V 23
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%D 2022
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2100977

T1 - Molecular pathogenesis of acetaminophen-induced liver injury and its treatment options
A1 - Xiaopeng CAI
A1 - Huiqiang CAI
A1 - Jing WANG
A1 - Qin YANG
A1 - Jun GUAN
A1 - Jingwen DENG
A1 - Zhi CHEN
J0 - Journal of Zhejiang University Science B
VL - 23
IS - 4
SP - 265
EP - 285
%@ 1673-1581
Y1 - 2022
PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B2100977

acetaminophen, also known as N-acetyl-p-aminophenol (APAP), is commonly used as an antipyretic and analgesic agent. APAP overdose can induce hepatic toxicity, known as acetaminophen-induced liver injury (AILI). However, therapeutic doses of APAP can also induce AILI in patients with excessive alcohol intake or who are fasting. Hence, there is a need to understand the potential pathological mechanisms underlying AILI. In this review, we summarize three main mechanisms involved in the pathogenesis of AILI: hepatocyte necrosis, sterile inflammation, and hepatocyte regeneration. The relevant factors are elucidated and discussed. For instance, N-acetyl-p-benzoquinone imine (NAPQI) protein adducts trigger mitochondrial oxidative/nitrosative stress during hepatocyte necrosis, danger-associated molecular patterns (DAMPs) are released to elicit sterile inflammation, and certain growth factors contribute to liver regeneration. Finally, we describe the current potential treatment options for AILI patients and promising novel strategies available to researchers and pharmacists. This review provides a clearer understanding of AILI-related mechanisms to guide drug screening and selection for the clinical treatment of AILI patients in the future.




Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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